DEVELOPMENT OF FLOATING GASTRORETENTIVE DRUG DELIVERY SYSTEM BASED ON A NOVEL EXCIPIENT FOR METFORMIN HYDROCHLORIDE USING MIXTURE DESIGN
نویسندگان
چکیده
منابع مشابه
Floating Drug Delivery of Nevirapine as a Gastroretentive System
A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating bead formulations were prepared by dispersing nevirapine together with calcium carbonate in a mixture of sodium alginate and hydroxypropyl methylcellulose solution and then drippi...
متن کاملFormulation Development and Evaluation of Gastro Retentive Floating Drug Delivery System for Novel Fluoroquinolone using Natural and Semisynthetic Polymers
The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various release retardants. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Floating tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK4M, HPMCK15M and HPMCK100M with effervescent mixtures by direct compression technique. Totally 9 formulations were...
متن کاملFormulation and Evaluation of Floating Gastroretentive Drug Delivery System of Diltiazem Hydrochloride
The present investigation describes the design and evaluation of monolithic gastro retentive dosage forms of diltiazem. Hydrophilic cellulose derivatives, Sodium alginate, Sodium carboxy methyl cellulose, Polyox, Methocel K100M in combination with Methocel E6LV are used as the rate controlling polymers. Sodium bicarbonate was incorporated as gas generating agent. Tablets were prepared by employ...
متن کاملFloating Microspheres: Recent Trends in the Development of Gastroretentive Floating Drug Delivery System
Oral controlled release systems are designed to release the drug in-vivo with prediction so as to increase efficacy, minimize adverse effects and increase bioavailability of drugs. Floating drug delivery systems (FDDSs) are expected to remain buoyant in a lasting way upon the gastric contents. The various buoyant preparations include hollow microspheres, granules, powders, tablets, capsules, pi...
متن کاملDesign and in vitro Evaluation of Gastroretentive Floating Drug Delivery System of Rosigilitazone Maleate
Rosigilitazone maleate is an anti-diabetic agent is used in the management of Type-II diabetes mellitus. The present investigation concerns the development of the sustained release floating matrix tablets which are designed to exhibit a prolonged gastric residence time and controlling the drug release from the dosage form. This system is useful particularly for achieving controlled plasma level...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Pharmacy and Pharmaceutical Sciences
سال: 2020
ISSN: 0975-1491,2656-0097
DOI: 10.22159/ijpps.2020v12i10.38678